Award

Mechanisms of Cellular Immortalization

Funder: National Institute on Aging

Funding type: research

Funder scheme: R01

Start date: 1989-04-01

End date: 2012-02-29

Investigator: WOODRING ERIK WRIGHT

Institution: UT SOUTHWESTERN MEDICAL CENTER

Funded outputs count: 76

Funder award ID: R01AG007992

OpenAlex ID: G8785885231

Genome integrity as a potential index of longevity in Ashkenazi Centenarian’s families

2024 · Mariana Andrawus, Gil Ben David, et al. · GeroScience · 9

APOE and immunity: Research highlights

2023 · Courtney M. Kloske, Christopher J. Barnum, et al. · Alzheimer s & Dementia · 36

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A Systematic Review of Innovative Diabetes Care Models in Low-and Middle-Income Countries (LMICs)

2014 · Yonah B. Esterson, Michelle Carey, et al. · Journal of Health Care for the Poor and Underserved · 47

Fatty Acid-Induced Production of Plasminogen Activator Inhibitor-1 by Adipose Macrophages Is Greater in Middle-Aged Versus Younger Adult Participants

2012 · Y. B. Esterson, P. Kishore, et al. · The Journals of Gerontology Series A · 10

A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci

2012 · Eimear E. Kenny, Itsik Pe'er, et al. · PLoS Genetics · 153

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Lifestyle Factors of People with Exceptional Longevity

2011 · Swapnil N. Rajpathak, Yingheng Liu, et al. · Journal of the American Geriatrics Society · 187

Genetic Studies Reveal the Role of the Endocrine and Metabolic Systems in Aging

2010 · Nir Barzilai, Ilan Gabriely · The Journal of Clinical Endocrinology & Metabolism · 62

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Gene-Gene Interactions Lead to Higher Risk for Development of Type 2 Diabetes in an Ashkenazi Jewish Population

2010 · Rosalind J. Neuman, Jon Wasson, et al. · PLoS ONE · 59

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Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians

2009 · Gil Atzmon, Miook Cho, et al. · Proceedings of the National Academy of Sciences · 244

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Telomere length regulates ISG15 expression in human cells

2009 · Zhenjun Lou, Jun Wei, et al. · Aging · 101

Altered States of Telomere Deprotection and the Two-Stage Mechanism of Replicative Aging

2009 · Ying Zou, Sandeep Misri, et al. · Molecular and Cellular Biology · 17

SGNP: An Essential Stress Granule/Nucleolar Protein Potentially Involved in 5.8s rRNA Processing/Transport

2008 · Chun-Hong Zhu, Jinyong Kim, et al. · PLoS ONE · 37

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Telomerase Assays in the Diagnosis and Prognosis of Cancer

2007 · Jerry W. Shay, Harold Werbin, et al. · Novartis Foundation symposium · 24

Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin‐dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies

2007 · Chun‐Hong Zhu, Vincent Mouly, et al. · Aging Cell · 301

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Function of AP-1 in Transcription of the Telomerase Reverse Transcriptase Gene (TERT) in Human and Mouse Cells

2005 · Masahiro Takakura, Satoru Kyo, et al. · Molecular and Cellular Biology · 107

Senescence and immortalization: role of telomeres and telomerase

2004 · Jerry W. Shay, Woodring E. Wright · Carcinogenesis · 737

Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomes

2004 · Ying Zou, Sergei M. Gryaznov, et al. · Proceedings of the National Academy of Sciences · 50

Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions

2004 · Hong Zhang, Brittney-Shea Herbert, et al. · Oncogene · 35

Does a Sentinel or a Subset of Short Telomeres Determine Replicative Senescence?

2004 · Ying Zou, Agnel Sfeir, et al. · Molecular Biology of the Cell · 293

Telomeric Recombination in Mismatch Repair Deficient Human Colon Cancer Cells after Telomerase Inhibition

2004 · Oliver E. Bechter, Ying Zou, et al. · Cancer Research · 185

Hallmarks of senescence in carcinogenesis and cancer therapy

2004 · Jerry W Shay, Igor B Roninson · Oncogene · 501

Homologous recombination in human telomerase‐positive and ALT cells occurs with the same frequency

2003 · Oliver E Bechter, Ying Zou, et al. · EMBO Reports · 67

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Developmental differences in the immortalization of lung fibroblasts by telomerase

2003 · Nicholas R. Forsyth, A. Patrice Evans, et al. · Aging Cell · 156

Human Telomerase Can Immortalize Indian Muntjac Cells

2002 · Y Zou · Experimental Cell Research · 49

Historical claims and current interpretations of replicative aging

2002 · Woodring E. Wright, Jerry W. Shay · Nature Biotechnology · 357