Epigenetic Signatures of Developmental Reprogramming in Target and Surrogate Tissues
Description: PUBLIC HEALTH RELEVANCE: Central Challenge in the field of developmental reprogramming to move from studies on target tissues and exposure-associated diseases in mouse models to exposure-induced epigenetic changes in surrogate tissues and health outcomes in human populations. In this application we will generate reference epigenomic maps to identify epigenetic alterations induced in target and surrogate tissues by developmental reprogramming, determine how these epigenetic "signatures" change over the life course, and whether they are affected by differences in the genetic background of exposed individuals. In this way we will identify those epigenetic marks that are the most robust against genetic background and most likely to be stable biomarkers of exposure and/or phenotypic consequence across the life course and in genetically diverse populations.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2016-06-01
End date: 2022-04-30
Investigator: MARISA S. BARTOLOMEI
Institution: BAYLOR COLLEGE OF MEDICINE
Funded outputs count: 16
Funder award ID: U01ES026719
OpenAlex ID: G6473523091