The mucosal immune system: effects of aging and chronic antigenic stimulation
Description: RELEVANCE TO PUBLIC HEALTH The proposed research will provide the first comprehensive analysis of age-associated immune changes in the human gut, the largest lymphoid organ in the body. The results will have significant clinical implications in terms of age-appropriate treatments and vaccine development for the ever-increasing older population. In addition, if our research shows that accelerated aging of the immune cells in the gut is reversible, this will stimulate efforts to identify novel therapeutic approaches for enhancing immune function in the elderly.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2009-09-30
End date: 2015-08-31
Investigator: RITA BRICKMAN EFFROS
Institution: UNIVERSITY OF CALIFORNIA LOS ANGELES
Funded outputs count: 13
Funder award ID: R01AG032422
OpenAlex ID: G3334108458