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Cytokines and Inflammatory Bowel Disease

Description: Project Narrative The present competitive renewal application will focus on two TNF superfamily members and their receptors, TL1A/DR3 and TWEAK/Fn14, for which increasing evidence suggests a major role in the pathogenesis of human and experimental Crohn¿s disease. The proposal will test the novel hypothesis that TL1A/DR3 and TWEAK/Fn14 play a protective role in normal gut homeostasis and in early disease compared to a proinflammatory role in the chronic phase of ileitis. The overall objective of this proposal is to investigate novel cytokine-based therapeutic strategies aimed at treating patients with IBD and begin to develop a cure for this devastating disease.
Funding type: research
Funder scheme: R56
Start date: 2010-08-15
End date: 2011-07-31
Investigator: FABIO COMINELLI
Institution: CASE WESTERN RESERVE UNIVERSITY
Subfield: Cancer Research
Funded outputs count: 53
Funder award ID: R56DK042191
OpenAlex ID: G4862219782
A missense mutation in Muc2 promotes gut microbiome and metabolome-dependent colitis-associated tumorigenesis
2025 · Giulio Verna, Stefania De Santis, et al. · Journal of Clinical Investigation · 3
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Cardiovascular Risk Factors and Diseases and Awareness of Related Burden in Women: Results of a Survey in Italian Pharmacies
2025 · Rita Del Pinto, Maria Vitale, et al. · High Blood Pressure & Cardiovascular Prevention · 3
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Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD
2024 · Giorgos Bamias, Paola Menghini, et al. · Gut · 57
Meta-analysis of oral microbiome reveals sex-based diversity in biofilms during periodontitis
2024 · Rita Del Pinto, Claudio Ferri, et al. · JCI Insight · 32
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Sex-based differences in prescribed medications, surgical procedures and disease-related complications in IBD
2024 · Celine Cumming, Emad Mansoor, et al. · Gut · 1
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Candida tropicalis Affects Candida albicans Virulence by Limiting Its Capacity to Adhere to the Host Intestinal Surface, Leading to Decreased Susceptibility to Colitis in Mice
2024 · Kyle Roberts, Abdullah Osme, et al. · Journal of Fungi · 9
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MSCs mediate long-term efficacy in a Crohn’s disease model by sustained anti-inflammatory macrophage programming via efferocytosis
2024 · Maneesh Dave, Atul Dev, et al. · npj Regenerative Medicine · 39
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An Overview of Chronic Kidney Disease Pathophysiology: The Impact of Gut Dysbiosis and Oral Disease
2023 · Serena Altamura, Davide Pietropaoli, et al. · Biomedicines · 51
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Oral health as a modifiable risk factor for cardiovascular diseases
2023 · Serena Altamura, Rita Del Pinto, et al. · Trends in Cardiovascular Medicine · 39
The gasdermin protein family: emerging roles in gastrointestinal health and disease
2023 · Giuseppe Privitera, Nitish Rana, et al. · Nature Reviews Gastroenterology & Hepatology · 71
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A Novel Probiotic Combination Ameliorates Crohn’s Disease–Like Ileitis by Increasing Short-Chain Fatty Acid Production and Modulating Essential Adaptive Immune Pathways
2023 · Luca Di Martino, Abdullah Osme, et al. · Inflammatory Bowel Diseases · 41
The Oral-Gut Axis: Periodontal Diseases and Gastrointestinal Disorders
2022 · Gretchen A Lam, Hala Albarrak, et al. · Inflammatory Bowel Diseases · 96
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Chronic stress induces colonic tertiary lymphoid organ formation and protection against secondary injury through IL-23/IL-22 signaling
2022 · Adrian Gomez-Nguyen, Nikhilesh Gupta, et al. · Proceedings of the National Academy of Sciences · 25
Live or let die: Translational insights and clinical perspectives of gasdermin B‐dependent intestinal epithelial cell fate
2022 · Giuseppe Privitera, Theresa T. Pizarro · Clinical and Translational Medicine · 4
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Novel Insights Into the Interactions Between the Gut Microbiome, Inflammasomes, and Gasdermins During Colorectal Cancer
2022 · Giuseppe Privitera, Nitish Rana, et al. · Frontiers in Cellular and Infection Microbiology · 29
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GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis
2022 · Nitish Rana, Giuseppe Privitera, et al. · Cell · 219
Candida tropicalis Infection Modulates the Gut Microbiome and Confers Enhanced Susceptibility to Colitis in Mice
2021 · Luca Di Martino, Carlo De Salvo, et al. · Cellular and Molecular Gastroenterology and Hepatology · 35
Parabacteroides distasonis induces depressive-like behavior in a mouse model of Crohn’s disease
2021 · Adrian Gomez-Nguyen, Abigail R. Basson, et al. · Brain Behavior and Immunity · 62
NOD2 drives early IL-33–dependent expansion of group 2 innate lymphoid cells during Crohn’s disease–like ileitis
2021 · Carlo De Salvo, Kristine-Ann Buela, et al. · Journal of Clinical Investigation · 45
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Interleukin 33 Triggers Early Eosinophil-Dependent Events Leading to Metaplasia in a Chronic Model of Gastritis-Prone Mice
2020 · Carlo De Salvo, Luca Pastorelli, et al. · Gastroenterology · 74
Intestinal Stem Cell Niche Defects Result in Impaired 3D Organoid Formation in Mouse Models of Crohn's Disease-like Ileitis
2020 · Ludovica F. Buttó, Adam Pelletier, et al. · Stem Cell Reports · 16
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Neutralization of IL-1α ameliorates Crohn’s disease-like ileitis by functional alterations of the gut microbiome
2019 · Paola Menghini, Daniele Corridoni, et al. · Proceedings of the National Academy of Sciences · 60
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TWEAK/Fn14 Is Overexpressed in Crohn’s Disease and Mediates Experimental Ileitis by Regulating Critical Innate and Adaptive Immune Pathways
2019 · Luca Di Martino, Abdullah Osme, et al. · Cellular and Molecular Gastroenterology and Hepatology · 15
IL-33 promotes recovery from acute colitis by inducing miR-320 to stimulate epithelial restitution and repair
2018 · Loris R. Lopetuso, Carlo De Salvo, et al. · Proceedings of the National Academy of Sciences · 119
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In-patient outcomes of Hematopoietic Stem Cell Transplantation in Patients with Immune Mediated Inflammatory Diseases: A Nationwide Study
2018 · Kathan Mehta, Palashkumar Jaiswal, et al. · Scientific Reports · 13
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