Contribuição da TARV no desenvolvimento de comorbidades não associadas à aids em PVHA assintomáticas
Description: Background: Despite the many benefits that follow antiretroviral therapy (ART) initiation, its chronic use contributes to the early aging of people living with HIV/Aids (PLWHA). The aim of this cross-sectional study was to trace the prevalence of and investigate possible renal, bone and metabolic changes, as well as cardiovascular risk in 94 asymptomatic PLWHA, relating them to the duration of ART use. Methods: Four groups were evaluated according to ART use: G1 (n=21), ART-naïve individuals; G2 (n=17), <2 years; G3 (n=40), 2-10 years; and G4 (n=16) on ART for more than 10 years. Results: Our results showed a high prevalence of dyslipidemic individuals (64%), especially in those under ART. Lower creatine phosphokinase levels were observed in G1 as compared to the others (p<0.05). Regarding the Framingham score, 12.1% of PLWHA showed moderate and high risk, and the highest proportion (38.5%) occurred in G4 (p= 0.003). A decrease in glomerular filtration rates ccurred in 20% of patients, which was also more sig ificant in G3 and G4 (p= 0.007). High prevalences of osteopenia and osteoporosis (53.2%) were found, especially in G1 and G4; however, G1 showed the lowest means for alkaline phosphatases (AP, p= 0.04 and BAP, p= 0.005) and osteocalcin (p= 0.005), in addition to higher vitamin-D concentrations (p= 0.04). Conclusion: Our study showed the possible contributory role of ART in these changes, which leads us to reflect on the need for specific conducts and patient care, pointing out the importance of individualized care in an attempt to increase life expectancy. (AU)
Funding type: publication
Funder scheme: Auxílio à Pesquisa - Publicações científicas - Artigo
Start date: 2021-03-01
End date: 2021-08-31
Investigator: Lenice Do Rosário de Souza
Institution: Universidade Estadual Paulista (UNESP). Campus de Botucatu. Faculdade de Medicina (FMB)
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 0
Funder award ID: 21/00164-0
OpenAlex ID: G3948009994