Clarify mechanism for lactational or aged infertility depending on newly discovered GPR61 in bovine gonadotroph
Description: The details of studies were published in Scientific Reports in 2021. The background of the study is infertility caused by suppressed functions of the central player of fertility control, gonadotrophs in pituitaries, dues to lactation stress and aging via unclarified mechanisms in cattle. This study clarified an important pathophysiological mechanism in brain, and causative substance, ethanolamine plasmalogen (EPl). Both lactation-stress and aging make worse the quality of EPl resulted in weak stimulation function for gonadotrophs. The primary reason of this successful discoveries is G-protein-coupled receptor 61 (GPR61), discovered by Kadokawa et al. in bovine pituitaries. This novel receptor is co- localize with GnRH receptors on the gonadotroph surface. Another reason of this success is utilizing a newly developed method, two-dimensional liquid chromatography-mass spectrometry. The obtained results can be developed also for human medicine.
Amount: ¥10,010,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Hiroya Kadokawa
Institution: Yamaguchi University
Funded outputs count: 7
Funder award ID: 18H02329
OpenAlex ID: G3951639397