Molecular mechanisms in the pathogenesis of myelodysplastic syndrome
Description: Myelodysplastic syndrome, which is more common in the elderly, is a clonal hematopoietic tumor that occurs from hematopoietic stem cells. In order to understand the functional decline of tissue stem cells due to environmental stress over life and the disease onset mechanism, we developed genetic analysis and verification using a mouse biological model in conjunction with analysis using clinical specimens. In this study, the analysis using existing gene expression data also strongly suggested the enhancement of inflammatory stress signal and the involvement in MDS disease state. Based on these findings, in order to prevent the onset of MDS, we have inhibited infection-stress signals as well as remodeled an epigenomic state of MDS stem cells into that of normal hematopoietic stem cells.
Amount: ¥18,590,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-07-19
End date: 2019-03-31
Investigator: Goro Sashida
Institution: Kumamoto University
Funded outputs count: 10
Funder award ID: 16KT0113
OpenAlex ID: G3986964082