Metabolism-based dissection of tumor microenvironment infiltrated by immune cells
Description: We found that anti-tumor effect of anti-PD-1 antibody was enhanced by combination with type 2 diabetes drug metformin. As one of the mechanisms, we found that tumor-infiltrating CD8T cells (CD8TIL) have a marked proliferative response and enhanced IFNγ production. This reaction was demonstrated to occur as part of the antioxidant stress response (active oxygen scavenging reaction) mediated by the Nrf2/mTORC1/p62 molecular group in CD8TIL by metformin. This study elucidated a completely new mechanism of the antitumor effect of metformin.
Amount: ¥43,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (A)
Start date: 2018-04-01
End date: 2023-03-31
Investigator: Heiichiro UDONO
Institution: Okayama University
Funded outputs count: 17
Funder award ID: 18H04033
OpenAlex ID: G4016162594