Investigation of lipid metabolism in Parkinson's disease
Description: PLA2G6 gene is a causative gene of Parkinson's disease with α-synucleinopathy. We reported that PLA2G6-deficient Drosophila exhibits defects in neurotransmission, progressive cell loss, and aggregation of α-synuclein. Lipid analysis of the brain reveals that alternation in phospholipids. We reported these results Proceedings of the National Academy of Sciences of the United States of America (PNAS). Recently, we found abnormal exosomes from PLA2G6 knock-out cells. This result also suggests that lipid alteration leads to abnormal clearance.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Akio Mori
Institution: Juntendo University
Funded outputs count: 5
Funder award ID: 18K15376
OpenAlex ID: G4023466602