Elucidation of the mechanism of oxidative stress response of molecular hydrogen mediated by membrane lipids
Description: Molecular hydrogen (H2) is known to act as an antioxidant and anti-inflammatory agent in the body, however, the mechanism of action remains unclear. In this study, we found that exposure of cells to H2 for only one hour changed the phospholipids that constitute the cell membrane. The phospholipids, which are known to function in the cellular organelles mitochondria and endosomes, were found to increase. Each of these is a cell organelle that is closely related to disease. We examined for changes in mitochondria-related metabolism, and found that many metabolites decreased within 1 hour of exposure to H2, indicating that transient oxidative stress was induced. We also examined endosomes and found that endosomal transport was delayed.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Masumi Iketani
Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Funded outputs count: 3
Funder award ID: 18K11092
OpenAlex ID: G4028088758