Therapeutic strategies to induce browning of white adipose tissue
Description: Project Narrative The pandemic of obesity is a major cause of the increased incidence of type 2-diabetes and cardiovascular diseases, which is expected to double by 2030 resulting in associated healthcare expenditure exceeding $100 billion in the United States alone. Consumption of dietary fat in obese individuals leads to storage in white adipose tissue (WAT) as opposed to its metabolism in brown and beige adipose (BAT); consequently, enhancement of BAT mass has the potential to diminish WAT mass and reduce the incidence of type 2 diabetes and cardiovascular disease. The proposed studies are designed to identify the processes controlling the recruitment of brown-like (beige) adipocytes in WAT depots of obese individuals and the knowledge gained has the potential of leading to the development of anti-obesity therapeutics.
Funding type: research
Funder scheme: R01
Start date: 2019-07-19
End date: 2023-04-30
Investigator: STEPHEN ROBERT FARMER
Institution: BOSTON UNIVERSITY MEDICAL CAMPUS
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 18
Funder award ID: R01DK117163
OpenAlex ID: G2702705009