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Targeting Succinate Signaling Impedes Periodontitis Progression

Description: Diabetic patients are prone to develop periodontal disease, which involves adaptive immune response, osteoclastogenesis and bone loss. We found that hyperglycemia elevated the level of succinate, an intermediate metabolite, and succinate signaling through its receptor may dysregulate the oral microenvironment homeostasis to increase inflammation and bone loss. This study will reveal how succinate enhances periodontitis progression associated with diabetes and the efficacy of targeting succinate signaling in protecting periodontal bone loss.
Funding type: research
Funder scheme: R01
Start date: 2018-04-01
End date: 2025-03-31
Investigator: DANA T GRAVES
Institution: NEW YORK UNIVERSITY
Subfield: Periodontics
Field: Dentistry
Funded outputs count: 23
Funder award ID: R01DE027074
OpenAlex ID: G1416065265
Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice
2025 · Fangxi Xu, Yuqi Guo, et al. · International Journal of Oral Science · 7
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The impact of aging on neutrophil functions and the contribution to periodontitis
2025 · Zi Wang, Anish Saxena, et al. · International Journal of Oral Science · 54
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Getting off tract: contributions of intraorgan microbiota to cancer in extraintestinal organs
2023 · Scott C Thomas, George Miller, et al. · Gut · 6
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A novel SUCNR1 inhibitor alleviates dysbiosis through inhibition of host responses without direct interaction with host microbiota
2023 · Scott C. Thomas, Yuqi Guo, et al. · Molecular Oral Microbiology · 8
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Targeting the succinate receptor effectively inhibits periodontitis
2022 · Yuqi Guo, Fangxi Xu, et al. · Cell Reports · 43
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Electronic Cigarette Use Promotes a Unique Periodontal Microbiome
2022 · Scott C. Thomas, Fangxi Xu, et al. · mBio · 70
Electronic cigarette use enriches periodontal pathogens
2022 · Fangxi Xu, Smruti Pushalkar, et al. · Molecular Oral Microbiology · 41
Comparative Effects of E-Cigarette Aerosol on Periodontium of Periodontitis Patients
2021 · Fangxi Xu, Eman Aboseria, et al. · Frontiers in Oral Health · 36
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Diabetic wound healing in soft and hard oral tissues
2021 · KANG I. KO, ANTON SCULEAN, et al. · Translational research · 175
Vaping, SARS-CoV-2, and Multisystem Inflammatory Syndrome: A Perfect Storm
2021 · Esha Brar, Anish Saxena, et al. · Frontiers in Pediatrics · 18
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FOXO1 expression in chondrocytes modulates cartilage production and removal in fracture healing
2021 · Zhenjiang Ding, Min Qiu, et al. · Bone · 10
Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly
2021 · Angela R. Kamer, Smruti Pushalkar, et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 47
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E-cigarettes use in the United States: reasons for use, perceptions, and effects on health
2020 · Sakshi Sapru, Mridula Vardhan, et al. · BMC Public Health · 223
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The Influences of Bioinformatics Tools and Reference Databases in Analyzing the Human Oral Microbial Community
2020 · Maria A. Sierra, Qianhao Li, et al. · Genes · 57
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Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations
2020 · Yuqi Guo, Sun Wook Cho, et al. · Endocrinology and Metabolism · 44
Electronic Cigarette Aerosol Modulates the Oral Microbiome and Increases Risk of Infection
2020 · Smruti Pushalkar, Bidisha Paul, et al. · iScience · 174
Diethyl Succinate Modulates Microglial Polarization and Activation by Reducing Mitochondrial Fission and Cellular ROS
2020 · Lixiang Wang, Yanli Zhang, et al. · Metabolites · 30
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The Microbiome, Malignant Fungating Wounds, and Palliative Care
2019 · Mridula Vardhan, Zia Flaminio, et al. · Frontiers in Cellular and Infection Microbiology · 54
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IFT80 Is Required for Fracture Healing Through Controlling the Regulation of TGF-β Signaling in Chondrocyte Differentiation and Function
2019 · Min Liu, Mohammed Alharbi, et al. · Journal of Bone and Mineral Research · 43
The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL
2019 · Berk Aykut, Smruti Pushalkar, et al. · Nature · 883
Virome and bacteriome: two sides of the same coin
2019 · Jonathan Stern, George Miller, et al. · Current Opinion in Virology · 63
Targeting cellular metabolism to reduce head and neck cancer growth
2019 · Jian Yang, Yuqi Guo, et al. · Scientific Reports · 62
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Inhibition of Karyopherin beta 1 suppresses prostate cancer growth
2019 · Jian Yang, Yuqi Guo, et al. · Oncogene · 64
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