Mechanisms of Hematopoietic Stem Cell Transformation
Description: PUBLIC HEALTH RELEVANCE: A major barrier to developing effective therapeutic interventions for blood disorders is our lack of understanding of what causes long-term hematopoietic stem cells (HSCLT) to overproduce specific types of mature blood cells in disease conditions. Our research project seeks to remove this critical roadblock by investigating how aberrant activation of myeloid-specific differentiation pathways in transformed HSCLT contributes to the development of myeloproliferative neoplasms (MPN) such as chronic myelogenous leukemia (CML). Our experiments address the exciting possibility that manipulating HSCLT differentiation pathways could represents a powerful approach to treat myeloid malignancies.
Funding type: research
Funder scheme: R01
Start date: 2008-04-03
End date: 2017-05-31
Investigator: EMMANUELLE PASSEGUE
Institution: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Funded outputs count: 27
Funder award ID: R01HL092471
OpenAlex ID: G5410621662