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Age related modulation of pain acceptance mechanism

Description: The effect of aging on intra-oral mucosal pain acceptance mechanism are not clear. Microglia regulate neuronal excitability and are involved in orofacial pain development. The effects of aging on mechanical allodynia in the intra oral focusing on the microglial pain regulation mechanism were investigated by behavioral observation experiments, immunohistochemistry experiments, and behavioral pharmacochemical experiments using aged mice. From these experimental results, it was revealed that aging effects property changes to inflammatory or anti-inflammatory microglia and expression of cytokines TNF-α and IL-10 released from each microglia, and as a result, it was suggested that mechanical hyperalgesia developed after oral mucosal injury was enhanced and sustained.

Funder: Japan Society for the Promotion of Science

Amount: ¥3,640,000

Funding type: fellowship

Funder scheme: Grant-in-Aid for Early-Career Scientists

Start date: 2018-04-01

End date: 2020-03-31

Investigator: Kentaro URATA

Institution: Nihon University

Topic: Pain Mechanisms and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 1

Funder award ID: 18K17157

OpenAlex ID: G4051975560

2022 · Tatsuki Oto, Kentaro Urata, et al. · The Tohoku Journal of Experimental Medicine · 6

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