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Functional roles of initiator methionine tRNA

Description: Genetic information is transcribed into mRNA and translated into protein on ribosomes, and finally, its function is exerted. In recent years, it has been reported that knockdown of translation-initiating proteins exhibits longevity, implying a correlation between the decrease in translation efficiency and lifespan extension. Translation initiation requires association of the initiator methionine tRNA with the 40S ribosome containing the translation initiation proteins. This study revealed that the initiator methionine tRNA is methylated in Caenorhabditis elegans and clarified its physiological function.

Funder: Japan Society for the Promotion of Science

Amount: ¥4,810,000

Funding type: research

Funder scheme: Grant-in-Aid for Scientific Research (C)

Start date: 2017-04-01

End date: 2021-03-31

Investigator: Keiko Hirota

Institution: Tokyo Women's Medical University(2018-2020)University of Tsukuba(2017)

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences