Molecular mechanisms of differentiation and metastasis of human gastrointestinal cancer stem cells
Description: Freshly isolated human gastrointestinal cancer stem cells (CSCs) and normal tissue stem cells, which form organoid in our culture system, were examined by comprehensive gene expression analysis. Differentiated colorectal non-CSCs in the culture were demonstrated to retrieve the stem cell features in association with activation of TWIST1, a key molecule of epithelial-mesenchymal transition process. Normal gastric tissue stem cells-derived organoid exhibited signet-ring cell carcinoma-like morphology by inhibition of E-cadherin expression. These molecules regulating the behavior of CSCs and tissue stem cells could possibly become therapeutic targets for cancer chemotherapy.
Amount: ¥4,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2015-04-01
End date: 2018-03-31
Investigator: Eishi Baba
Institution: Kyushu University
Funded outputs count: 4
Funder award ID: 15K08970
OpenAlex ID: G4068324643