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Molecular Mechanisms of Rapamycin - Induced Reversal of Cardiac Aging

Description: Project Narrative Aging is a dominant risk factor for cardiovascular disease and also impairs baseline cardiac function. The underlying mechanisms of cardiac aging are not well established and no intervention has been developed. This study will lead to fundamental insights into key regulators of cardiac healthspan and help guide future translational studies of rapamycin treatment for cardiac aging or heart failure with preserved ejection fraction, a previously untreatable disease of aging.
Funding type: research
Funder scheme: R00
Start date: 2019-06-01
End date: 2022-12-31
Investigator: YING ANN CHIAO (lead)
Subfield: Aging
Funded outputs count: 7
Funder award ID: R00AG051735
OpenAlex ID: G1519888846
Hyperactive mTORC1/4EBP1 signaling dysregulates proteostasis and accelerates cardiac aging
2024 · Weronika Zarzycka, Kamil A. Kobak, et al. · GeroScience · 13
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Sexually dimorphic effects of SARM1 deletion on cardiac NAD + metabolism and function
2022 · Hina Lateef Nizami, Keaton E. Minor, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 10
Harnessing NAD+ Metabolism as Therapy for Cardiometabolic Diseases
2022 · Akash Chakraborty, Keaton E. Minor, et al. · Current Heart Failure Reports · 6
Age and Sex Differences in Heart Failure With Preserved Ejection Fraction
2022 · Kamil Aleksander Kobak, Weronika Zarzycka, et al. · Frontiers in Aging · 24
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NAD + Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy
2021 · Ying Ann Chiao, Akash Deep Chakraborty, et al. · Circulation Heart Failure · 65
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Myocardial Hypertrophy and Compensatory Increase in Systolic Function in a Mouse Model of Oxidative Stress
2021 · Rohan Varshney, Rojina Ranjit, et al. · International Journal of Molecular Sciences · 15
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Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice
2020 · Ying Ann Chiao, Huiliang Zhang, et al. · eLife · 137