Control of calcium flux and mitochondrial fission by the Charcot Marie Tooth disease protein Mfn2.
Description: Project Narrative Charcot-Marie-Tooth disease (CMT) is a hereditary neuropathy caused by gene mutations that lead to demyelination and axon degeneration of peripheral neurons. This proposal follows through on data suggesting that mutations in one of the CMT genes called Mfn2 affects mitochondrial fission and axonal transport in unexpected ways. A successful outcome of this project can provide new insight into the underlying causes of the disease and it may point the way towards developing novel treatment strategies.
Funding type: research
Funder scheme: R01
Start date: 2021-01-01
End date: 2025-12-31
Investigator: CARLA M KOEHLER
Institution: UNIVERSITY OF CALIFORNIA LOS ANGELES
Funded outputs count: 5
Funder award ID: R01NS120690
OpenAlex ID: G9000881108