Adverse effect on age-related brain function by environmental and social stress and a preventive role of food factors
Description: Effects of aging on social stress, such as isolation and confrontation, induced physiological responses were investigated using young, middle-aged, and old mice (C57BL/6N and BALB/c). A stress response via activated HPA axis was induced in each aged mice. It was suggested that isolation stress for a long period may affect the lipid metabolism and induce intracerebral inflammation, especially in middle aged mice. It was found that the expressions of two genes in the liver or the hippocampus were reduced or induced by social stress. These two genes could be used as a new stress related marker.
Amount: ¥15,730,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Kayoko Shimoi
Institution: University of Shizuoka
Funded outputs count: 5
Funder award ID: 18H03194
OpenAlex ID: G4096645247