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Repairing the Kidney Endothelium via Targeted Extracellular Matrix Modifiers

Description: PROJECT NARRATIVE This study investigates a new strategy to deliver bioactive agents to specific regions of the kidney vasculature, called the tissue extracellular matrix. The science contained within this application develops and validates a dual functional nanomaterial to repair and protect the damaged endothelium of the kidney that is a primary contributor to chronic kidney disease leading to kidney failure and necessitating dialysis or kidney transplantation.
Funding type: research
Funder scheme: R01
Start date: 2018-09-15
End date: 2024-07-31
Investigator: JASON A WERTHEIM
Institution: UNIVERSITY OF ARIZONA
Subfield: Surgery
Field: Medicine
Funded outputs count: 6
Funder award ID: R01DK113168
OpenAlex ID: G808254743
Coalescing nephron and ureteric bud progenitors potentiates nephrogenesis in recellularized kidney scaffolds
2026 · Ashwani Kumar Gupta, Ekta Minocha, et al. · Communications Materials
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A kidney organoid-based readout to assess disease activity in primary and recurrent focal segmental glomerulosclerosis
2025 · Ashwani Kumar Gupta, Ekta Minocha, et al. · Kidney International · 14
Toward discovering a novel family of peptides targeting neuroinflammatory states of brain microglia and astrocytes
2023 · K. M. Koss, T. Son, et al. · Journal of Neurochemistry · 6
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Autophagy Enhances Longevity of Induced Pluripotent Stem Cell-Derived Endothelium via mTOR-Independent ULK1 Kinase
2022 · Katherine E Hekman, Kyle M Koss, et al. · Stem Cells Translational Medicine · 6
Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium
2022 · Bilal A. Naved, Joseph V. Bonventre, et al. · Kidney International · 55
Poly(ethylene glycol)-crosslinked gelatin hydrogel substrates with conjugated bioactive peptides influence endothelial cell behavior
2019 · Jimmy Su, Simon C. Satchell, et al. · Biomaterials · 69
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