Elucidation of roles of metabolic disorder in proximal tubules and its sensor in progression of diabetic nephropathy
Description: In proximal tubular epithelial cells (PTEC) in diabetes, increase in glucose and sodium flux through sodium-glucose cotransporter (SGLT) due to increase in urine glucose causes metabolic stress on these cells. Therefore, roles of thioredoxin-interacting protein (TXNIP), a metabolic stress sensor, in PTEC in progression of diabetic nephropathy should be elucidated. In diabetic STZ mice, blood glucose and urinary albumin increased compared to controls. Protein expression of TXNIP increased in skeletal muscle but did not increased in liver and proximal tubules. In STZ mice, oral administration of SGLT2 inhibitor decreased blood glucose and caused decrease in TXNIP expression in skeletal muscles but did not alter TXNIP expression in liver and proximal tubules.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2022-03-31
Investigator: Shimpei Fujimoto
Institution: Kochi University
Funded outputs count: 0
Funder award ID: 18K11129
OpenAlex ID: G4112956629