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DE-SC0012704

Funded outputs count: 56
Funder award ID: DE-SC0012704
OpenAlex ID: G4130418780
Structural Insights into Brain-Penetrant EGFR Tyrosine Kinase Inhibitors with Enhanced Potency
2026 · Abigail M. Lantry, Tess M. Weber, et al. · ACS Medicinal Chemistry Letters
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Dehydration-Responsive Left-Handed G-Quadruplexes Expand the Sequence Repertoire
2026 · Yun Chen, Andrew Hendrickson, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Copper-Based Nanostructures as Peroxidase Mimics: Elucidating the Roles of Shape, Composition, and Chloride Ion Modulation
2026 · Ghazaleh Salmanian, Lihua Zhang, et al. · ACS Nanoscience Au
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Surface Functionalization of Thermoplastic Polyurethane Scaffolds to Enhance Microparticle Attachment
2026 · Megan C. Welch, Courtney K. Rowe, et al. · ACS Biomaterials Science & Engineering
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De novo design of miniprotein inhibitors of bacterial adhesins
2026 · Adam M. Chazin-Gray, Tuscan R. Thompson, et al. · Nature Communications
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Widespread Biosynthesis of Thiohistidine Dipeptides in Bacteria
2026 · Marissa L. Abbott, Jacob T. Leeman, et al. · Journal of the American Chemical Society
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Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRAS
2026 · Matthew J. Whitley, Marcin Dyba, et al. · Nature Communications
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Strategy for modular assembly of tetravalent, multispecific antibodies
2026 · Evan Mallette, Levi L. Blazer, et al. · Protein Science
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Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity
2026 · Nico J. Seidler, Monica R. MacDonald, et al. · Angewandte Chemie International Edition
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A sequence motif enables widespread use of noncanonical redox cofactors in natural enzymes
2026 · Samer Saleh, Ning-Hsiang Hsu, et al. · Nature Chemical Biology
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X-ray crystallographic fragment screening reveals novel and conformationally dynamic ligand-binding sites in Mycobacterium tuberculosis FtsZ
2026 · Kaylen R. Meeks, Edwin O. Lazo, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Isoprenoid Binding and Substrate Channeling in Drimenol Synthase, a Bifunctional Class II Terpene Cyclase-Phosphatase
2026 · Kristin R. Osika, Mason E. Leffler, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1-mediated cell-intrinsic resistance
2026 · Jianyong Liu, Qing-Li He, et al. · Nature Communications · 5
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Mechanical Caging of Nucleic Acids Enabled by Light‐Activated Synthetic Molecular Motors
2026 · Yuchen Ma, Erika McCarthy, et al. · Angewandte Chemie International Edition
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Structural and mechanistic insights into protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus nucleocapsid protein
2026 · Vanessa Moresco, Aura R. Garrison, et al. · Nature Communications
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De novo design of autocatalytically forming intra- and intermolecular isopeptide bonds to construct rigid covalent protein assemblies
2026 · Lukas F Milles, Evelyn B Huddy, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Scanning X-ray microdiffraction studies of protein accumulation and tissue loss in thin sections of human brain tissue in Alzheimer’s disease
2026 · Prakash Nepal, Abdullah Al Bashit, et al. · Scientific Reports
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New Insights into Binding of G-segment DNA to the Active Site of Escherichia coli Topoisomerase III
2026 · Kemin Tan, Thirunavukkarasu Annamalai, et al. · Scientific Reports
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Single-component self-assembling protein nanoparticles displaying stabilized prefusion-closed hemagglutinin trimers for influenza vaccine development
2026 · Yi-Nan Zhang, Xueyong Zhu, et al. · Nature Communications · 1
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A structural bridge between dengue virus tandem xrRNAs facilitates coordination of exonuclease resistance
2026 · Elizabeth Spear, Zoe O'Donoghue, et al. · mBio
Structural characterization of intermediates in Sec1/Munc18 protein-catalyzed SNARE assembly
2026 · Abigail E. Stanton, Isabella Midura, et al. · Journal of Biological Chemistry
Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses
2026 · Hannah C. Geisler, Hannah C. Safford, et al. · Advanced Materials
Epitope-guided Detection of a Molecular Glue-induced Ternary Complex Using Engineered Synthetic Antibody Fragments
2026 · Kelly M. O’Leary, Tomasz Slezak, et al. · Journal of Molecular Biology
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Solvent‐Guided Chiral Assemblies and Chemical Doping of OEG‐Functionalized Conjugated Polymers
2026 · Sanghyun Jeon, Justin Scott Neu, et al. · Advanced Materials
Dysregulation of Human ClpP Using Small Molecules with Piperazine-Based Scaffold for Diffuse Intrinsic Pontine Glioma Therapy Validated by Patient-Derived Tumor Organoids
2026 · Morena Miciaccia, Domenico Armenise, et al. · Journal of Medicinal Chemistry · 1
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