Solute carrier proteins in efferocytosis and inflammation
Description: Public Health Relevance Phagocytosis of apoptotic cells is fundamentally important for many biological processes, and defects in cell clearance have been linked to multiple inflammatory diseases. Similarly, mutations in solute carrier (Slc) family proteins have been linked to >100 human diseases. This proposal addresses the role of the Slc genes and proteins during the process of apoptotic cell clearance, in the context of inflammation models. Since SLCs are membrane proteins and have been shown to be drug targets, the results of this proposal could have significant therapeutic implications for diseases such as autoimmune diseases, lung inflammation, atherosclerosis, and acute kidney injury, where both the apoptotic cell clearance and SLC function have been previously linked.
Funding type: research
Funder scheme: R01
Start date: 2021-01-25
End date: 2025-12-31
Investigator: KODI S RAVICHANDRAN
Institution: WASHINGTON UNIVERSITY
Funded outputs count: 17
Funder award ID: R01AI159551
OpenAlex ID: G9000920974