The Relationship between Low Vitamin D Status and Hypertension/Cardiovascular Disease in Japanese: Epidemiological and Basic Approaches
Description: In cross sectional study of elderly women, low serum 25-hydroxyvitamin D (25OHD) concentration were detected as siginificant factors for elevation of blood pressure independent of age, BMI, serum PTH concentration, and eGFR by multiple regression analysis. On the other hand, we could not find no direct relationship between serum 25OHD concentration and blood pressure in the subjects including young generation.In basic study, blood pressure of vitamin D receptor gene knockout mice (VDRKO) was significantly higher than that of wild type. We confirmed that vitamin D was a negative regulator of renal Renin gene expression independent of serum Ca concentration, and increase of renal epithelial sodium channel (ENaC) gene expression would contribute to increase of blood pressure in VDRKO.
Amount: ¥4,290,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Naoko Tsugawa
Institution: Osaka Shoin Women's University
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 7
Funder award ID: 17K00895
OpenAlex ID: G4148525703