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Diversity of macrophages in noncommunicable disease

Description: Macrophages exhibit diverse phenotypes and functions. For instance, macrophages play pivotal roles from the beginning of chronic inflammation to the phase of tissue remodeling and dysfunction in noncommunicable diseases, including cardiovascular disease and cancer. It is likely that dysfunction in macrophages would lead to tissue dysfunction in aging and various diseases. In this study, we aimed to elucidate as to how macrophage diversity is regulated by intracellular and extracellular cues. We mainly focused on the changes in the epigenome and at the single-cell level. We found that aging-associated changes in tissue macrophages may alter tissue homeostasis in the heart.

Funder: Japan Society for the Promotion of Science

Amount: ¥18,590,000

Funding type: research

Funder scheme: Grant-in-Aid for Scientific Research (B)

Start date: 2017-07-18

End date: 2020-03-31

Investigator: Ichiro Manabe

Institution: Chiba University

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences