Molecular mechanisms linking epigenetic changes to longevity
Description: Project Narrative Epigenetic alterations are a hallmark of aging and contribute to a variety of age-related diseases including cancer, neurodegeneration, and metabolic disorders. However, specific epigenetic modifications, such as an H3K4me3 deficiency, promote longevity and induce transgenerational benefits. This project will identify novel molecular mechanisms that govern these positive effects on aging and have the potential to be targeted to protect against the rapidly growing public health burden of age-related diseases.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R00
Start date: 2020-08-01
End date: 2025-11-30
Investigator: CARLOS GIOVANNI SILVA-GARCIA
Institution: BROWN UNIVERSITY
Funded outputs count: 4
Funder award ID: R00AG065508
OpenAlex ID: G9000903299