The role of time-restricted feeding on obesity and cardiometabolic health
Description: Obesity affects more than one third of the US population and is associated with multiple cardiovascular risk factors and heart disease, including congestive heart failure and coronary artery disease. Most research studies and clinical programs have focused on the balance of calories consumed and expended to explain the obesity epidemic and to induce weight loss in individuals and populations. However, emerging data suggest that the timing of calories consumed, not just the amount of calories, can have significant effects on body weight and metabolism. Studies in animals and small studies in humans have shown that feeding mistiming results in weight gain, increased body fat and ectopic fat, impaired glucose homeostasis and dyslipidemia. Furthermore, early studies suggest that actively synchronizing food intake with the circadian rhythm may enhance weight loss and improve cardiometabolic parameters including glucose and lipids. We have assembled a talented, multidisciplinary team to conduct synergistic basic, clinical and population studies around the overarching hypothesis that the mistiming of caloric intake relative to normal circadian rhythm contributes to obesity and adverse cardiometabolic outcomes including impaired glucose homeostasis, dyslipidemia, and hypertension. Aim 1 for the Center will be to investigate the effects of time-restricted feeding on obesity and cardiometabolic outcomes, through the conduct of the 3 projects below: Basic Project: Rexford Ahima, MD, PhD ' 'Metabolic and Cardiovascular Effects of Time-restricted Feeding in Obese Mice' Clinical Project: Nisa Maruthur, MD, MHS ' 'The Effect of Time-Restricted, Isocaloric Feeding on Weight: A Randomized Feeding Study in Obese Adults' Population Project: Wendy Bennett, MD, MPH 'The Impact of Timing of Eating on Weight: A Multi-site Cohort Study using The Metabolic Compass Mobile Application' Aim 2 for the Center will be to train a cadre of translational researchers in obesity and cardiovascular disease research through a specially designed: Training Program: Edgar (Pete) Miller, MD, PhD, will recruit 3 fellows interested in this area and provide rigorous, interdisciplinary training to increase the capacity for translational research in this area. Aim 3 for the Center will be to participate fully in the AHA SFRN Program, and develop robust new collaborations across already funded Centers, including with the Hopkins Go Red for Women Center, and with the new Obesity Centers.
Funder: American Heart Association
Amount: $667,500
Funding type: research
Funder scheme: Strategically Focused Research Network
Start date: 2017-04-01
End date: 2021-03-31
Investigators: Jeanne Clark, Jeanne Clark
Institution: Johns Hopkins University JHURA
Funded outputs count: 8
Funder award ID: 17SFRN33560006
OpenAlex ID: G416407470