Application of DFAT cell for periodontal regeneration
Description: Periodontitis makes dental treatment difficult because prosthesis device becomes unstable by highly ridge absorption. Recently, mesenchymal stem cell-based approaches have been researched for regenerative medicine. However, tissue harvesting is limited. Mature adipocyte-derived dedifferentiated fat cells (DFAT) which established by ceiling culture methods are easily isolated from a small amount of adipose tissue and are homogeneous cell population with high purity. DFAT cells can be established from buccal fat, we revealed that DFAT cells facilitate periodontal regeneration in inbred rat fenestration defects. Furthermore, we investigated the periodontal regenerative potential of DFAT cells in swine as preclinical examine. In consequence, newly formed periodontal ligament, cementum and alveolar bone were observed in DAFT cells transplantation group. However, we couldn’t but change an animal to use because of easily controls rearing and the number of the suitable samples.
Amount: ¥2,990,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2016-04-01
End date: 2018-03-31
Investigator: Daisuke AKITA
Institution: Nihon University
Funded outputs count: 4
Funder award ID: 16K20519
OpenAlex ID: G4179437384