Leveraging genomics strategies to generate adult neurons from iPSCs and somatic cells
Description: Recent advances have made it possible to derive myriad specialized human cells from stem cells or by directly reprogramming cell identity. However, these derived cells are generally arrested at a fetal developmental stage, and do not mature to function like adult cells. We will use new genomic, epigenetic, cell reprogramming, and manipulation methods to discover how to derive mature cells, aiming to generate mature neurons for use in neurobiology research, disease modeling, and drug screening.
Amount: A$1,593,000
Funding type: research
Funder scheme: Project Grants - Standard Project Grant
Start date: 2017-01-01
End date: 2020-12-31
Investigator: Ryan Lister
Institution: University of Western Australia
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 10
Funder award ID: 1130168
OpenAlex ID: G4193254676