Elucidating Effects of Fibrosis on Aged Stem Cells with Dynamic Biomaterials
Description: PROJECT NARRATIVE Fibrosis, which causes dysfunction and ultimate failure of numerous tissues with aging, is characterized in part by increased tissue stiffness. Despite the profound impact of fibrosis on the health of our aging population, no adequate model system exists to study fibrotic stiffening on individual cells in real-time. This project aims to develop a dynamic material platform that enables user-directed manipulation of stiffness and to apply this system to identify aging-related changes in muscle stem cells that could lead to novel therapies to improve muscle function in aged individuals.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R00
Start date: 2021-08-15
End date: 2025-12-31
Investigator: CHRISTOPHER MATTHEW MADL
Institution: UNIVERSITY OF PENNSYLVANIA
Funded outputs count: 4
Funder award ID: R00AG071738
OpenAlex ID: G9000872990