Award

Investigating the Impact of Telomere Specific Oxidative Base Damage in Cellular Aging

Description: Project Narrative Telomeres are essential genetic structures at the interface between cellular aging and carcinogenesis. In this fellowship I will use a model of telomere specific oxidative base damage in normal cells to determine the DNA damage signaling response, immune signaling status, and cellular outcomes in response to a single induction of telomere oxidative stress. This work will provide meaningful insight on the contribution telomere base damage has on cellular aging, and will inform future basic and clinical research related to promoting human healthspan and preventing or delaying aging-related disease including cancer.

Funder: National Institute on Aging

Funding type: fellowship

Funder scheme: F32

Start date: 2020-06-01

End date: 2023-05-31

Investigator: RYAN P BARNES

Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 7