Award

82071589

Funder: National Natural Science Foundation of China

Funded outputs count: 12

Funder award ID: 82071589

OpenAlex ID: G4219201162

ZNRF2-mediated CD-M6PR degradation and lysosomal dysfunction aggravate cellular senescence and aging

2026 · Tingting Zhao, Weitong Xu, et al. · GeroScience · 1

Hyperglutaminolysis drives senescence and aging through arginine-mTORC1 axis activation

2026 · Honghan Chen, Ning Huang, et al. · Signal Transduction and Targeted Therapy · 6

Celastrol Targets Hsc70‐Bim Interaction as a Novel Senolytic to Extend Lifespan and Mitigate Organ Fibrosis

2026 · Weitong Xu, Honghan Chen, et al. · Phytotherapy Research · 1

mTORC2: A neglected player in aging regulation

2024 · Weitong Xu, Honghan Chen, et al. · Journal of Cellular Physiology · 6

AMPK‐upregulated microRNA‐708 plays as a suppressor of cellular senescence and aging via downregulating disabled‐2 and mTORC1 activation

2024 · Jian Zhang, Hui Gong, et al. · MedComm · 12

CVD phenotyping in oncologic disorders: cardio-miRNAs as a potential target to improve individual outcomes in revers cardio-oncology

2024 · Ming Yang, Tiepeng Li, et al. · Journal of Translational Medicine · 8

GPD1L As a prognostic biomarker associated with Treg immune-infiltration and lipid metabolism for Clear cell renal cell carcinoma

2023 · Ming Yang, Chuhui Gong, et al. · Research Square

APPL1 Is a Prognostic Biomarker and Correlated with Treg Cell Infiltration via Oxygen-Consuming Metabolism in Renal Clear Cell Carcinoma

2023 · Ming Yang, Chuhui Gong, et al. · Oxidative Medicine and Cellular Longevity · 4

SeHed, a novel gene expression system with stress-evoked hydrogen peroxide elimination property and anti-aging effect

2022 · Ning Huang, Honghan Chen, et al. · Signal Transduction and Targeted Therapy · 5

Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy

2022 · Jiao Zhou, Honghan Chen, et al. · Frontiers in Pharmacology · 28

Pan-mTOR inhibitors sensitize the senolytic activity of navitoclax via mTORC2 inhibition-mediated apoptotic signaling

2022 · Weitong Xu, Tingting Zhao, et al. · Biochemical Pharmacology · 18

miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD+/SIRT inactivation

2022 · Hui Gong, Honghan Chen, et al. · Signal Transduction and Targeted Therapy · 99