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Methylglyoxal drives astrocyte senescence to mediate neurodegeneration in Alzheimer's disease

Description: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing a new and alternative strategy to treat Alzheimer’s disease (AD) by eliminating senescent astrocytes that contribute to inflammation and neurodegeneration. We will achieve this by determining the role of the glycolytic by-product methylglyoxal in driving astrocyte senescence and neurodegeneration in AD. These studies will develop novel therapeutic targets to inhibit cellular senescence in the brain and reduce the risk of AD.
Funding type: research
Funder scheme: R01
Start date: 2020-08-01
End date: 2025-07-31
Investigator: PANKAJ KAPAHI
Institution: BUCK INSTITUTE FOR RESEARCH ON AGING
Funded outputs count: 17
Funder award ID: R01AG068288
OpenAlex ID: G6142202875
Why studying females reveals more about aging: The reproductive resilience hypothesis for the evolution of sex-specific aging
2026 · Parminder Singh, Vineeta Tanwar, et al. · Cell · 3
Reduction of glycation stress as a geroscience intervention: protocol for a pilot RCT in postmenopausal women
2026 · Vineeta Tanwar, Pankaj Kapahi, et al. · npj Aging
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Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence
2025 · Parminder Singh, Ravinandan Venkatasubramanian, et al. · Aging · 8
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Growth hormone excess drives liver aging via increased glycation stress
2025 · Parminder Singh, Anil Gautam, et al. · Aging · 4
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Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan
2025 · Lauren A. Wimer, Kiyomi R. Kaneshiro, et al. · Cell Reports · 5
Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans
2025 · Yifan Xiang, Vineeta Tanwar, et al. · eLife · 1
Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans
2025 · Yifan Xiang, Vineeta Tanwar, et al. · eLife · 1
Glycation metabolites predict incident age-related comorbidities and mortality in older people with HIV
2025 · Xi Qiao, Liangliang Zhang, et al. · GeroScience · 1
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Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans
2025 · Yifan Xiang, Vineeta Tanwar, et al. · eLife · 1
Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans
2024 · Yifan Xiang, Vineeta Tanwar, et al. · eLife
Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans
2024 · Yifan Xiang, Vineeta Tanwar, et al. · eLife · 8
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Pharyngeal Pumping Assay for Quantifying Feeding Behavior in Caenorhabditis elegans
2024 · Muniesh Muthaiyan Shanmugam, Pankaj Kapahi · BIO-PROTOCOL · 6
Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans
2023 · Muniesh Muthaiyan Shanmugam, Jyotiska Chaudhuri, et al. · eLife · 11
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Immune checkpoint inhibitors as senolytic agents
2022 · Parminder Singh, Pankaj Kapahi, et al. · Cell Research · 7
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Decision letter: Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans
2022 · eLife
Editor's evaluation: Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans
2022 · Scott F Leiser · eLife
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Comprehensive proteomic quantification of bladder stone progression in a cystinuric mouse model using data-independent acquisitions
2022 · Jacob Rose, Nathan Basisty, et al. · PLoS ONE · 5
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