Methionine Cycle as a Mechanistic Hub for the Hallmarks of Aging
Description: Project Narrative (NIH) We propose the Hallmarks of Aging are mediated and coordinated by the branches of methionine metabolism: the methionine cycle, the transsulfuration pathway and the polyamine/salvage pathway. Nutrient sensing, itself a Hallmark of Aging, strongly impacts methionine metabolism through signaling from the insulin/IGF receptor. We will use novel mutants of the Drosophila insulin receptor to dissect how methionine metabolism integrates the Hallmarks of Aging.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2023-09-15
End date: 2028-05-31
Investigator: ANDREY A PARKHITKO
Institution: BROWN UNIVERSITY
Funded outputs count: 11
Funder award ID: R01AG082801
OpenAlex ID: G9000895964