Chemotherapy-induced vascular cognitive impairment: role of endothelial senescence
Description: PROJECT NARRATIVE The proposed research is relevant to public health as cancer treatment with chemotherapeutic drugs induces progressive, long-lasting adverse effects on cognitive function in 30 to 50% of patients, yet its pathogenesis is not well understood. Increasing clinical and experimental evidence suggest that chemotherapeutic agents cause cerebral vascular damage, which impairs cerebral blood flow and vascular responses contributing to chemotherapy-induced cognitive impairment. The discovery of the cellular mechanisms responsible for decreased cognitive capacity after cancer treatment is ultimately expected to enhance understanding of the pathogenesis of the disease and will lead to the development of novel therapeutic interventions for prevention; thus, the proposed research is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will help to reduce the burdens of cancer.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2021-01-01
End date: 2026-12-31
Investigator: ANNA CSISZAR
Institution: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Funded outputs count: 82
Funder award ID: R01CA255840
OpenAlex ID: G9000878214