PTH Signaling through LRP6
Description: PUBLIC HEALTH RELEVANCE: Osteoporosis is a major health problem affecting millions of Americans, with women and men who have had hyperlipidemia and associated atherosclerosis being particularly vulnerable. We recently found that bone marrow mesenchymal stem cells (MSCs) lose their osteoblast differentiation potential in hyperlipidemia mice. The work proposed in this application will investigate the mechanisms of how bioactive lipids produced during hyperlipidemia negatively act on osteoblast lineage cells with hope to yield new strategies to simultaneously treat both osteoporosis and hyperlipidemia/atherosclerosis.
Funding type: research
Funder scheme: R01
Start date: 2009-09-09
End date: 2020-02-29
Investigator: MEI WAN
Institution: JOHNS HOPKINS UNIVERSITY
Funded outputs count: 11
Funder award ID: R01DK083350
OpenAlex ID: G2282025437