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Targeting adipose tissue thermogenesis for age-related vascular cognitive impairment

Description: Narrative Vascular cognitive impairment is one of the most prevalent causes of age-related decline of brain health. Vascular changes precede neuronal alterations thus they provide targets for potential, new therapeutic approaches. Thermogenesis positively affects metabolism and systemic inflammation thus it can be used as a therapeutic option to boost cerebrovascular health and cognitive status.

Funder: National Institute on Aging

Funding type: career_development

Funder scheme: K01

Start date: 2021-09-30

End date: 2026-08-31

Investigator: PRIYA BALASUBRAMANIAN

Institution: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

Funded outputs count: 32

Funder award ID: K01AG073613

OpenAlex ID: G9000902146

Time-restricted feeding rejuvenates cerebrovascular function and preserves cognition during aging

2026 · Stefano Tarantini, Madison Milan, et al. · Research Square

Senolytic treatment with dasatinib and quercetin selectively improves cardiac autonomic balance in obesity

2026 · Mahesh Kumar Sivasubramanian, Raisa Monteiro, et al. · GeroScience · 1

Circulating factors as modifiable therapeutic targets in brain and cerebrovascular aging: Insights from heterochronic parabiosis

2026 · Rafal Gulej, Dorina Nagy, et al. · Advances in Translational Research · 5

Rejuvenation of the Aged Cerebrovascular System via Protein Corona–Guided Fusogenic Liposome Delivery

2026 · Santny Shanmugarama, Till Gronemann, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1

Lipid-laden endothelial cells exhibit a transcriptomic signature linked to blood–brain barrier dysfunction, metabolic reprogramming, and increased inflammation in the aging brain

2026 · Sarah Otu-Boakye, Duraipandy Natarajan, et al. · GeroScience · 9

Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging

2026 · Madison Milan, Eva Troyano‐Rodriguez, et al. · Aging Cell · 25

Age-Related Alterations of Cerebral Autoregulation

2025 · Anna Ungvari, Attila Kállai, et al. · Life · 14

Optical Coherence Tomography-Based Methodology for In Vivo Visualization and Quantification of Vascular Features and Collagen in Mouse Ovaries

2025 · Sharon Negri, FENG YAN, et al.

Optical Coherence Tomography-Based Methodology for In Vivo Visualization and Quantification of Vascular Features and Collagen in Mouse Ovaries

2025 · Sharon Negri, FENG YAN, et al.

Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments

2025 · Rafal Gulej, Roland Patai, et al. · GeroScience · 28

Effects of NAD+ supplementation with oral nicotinamide riboside on vascular health and cognitive function in older adults with peripheral artery disease: Results from a pilot 4-week open-label clinical trial

2025 · Zsofia Szarvas, Zeke A. Reyff, et al. · Journal of Pharmacology and Experimental Therapeutics · 18

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

2025 · Boglarka Csik, Ádám Nyúl‐Tóth, et al. · Aging Cell · 44

Chronic β3 adrenergic agonist treatment improves neurovascular coupling responses, attenuates blood-brain barrier leakage and neuroinflammation, and enhances cognition in aged mice

2025 · Duraipandy Natarajan, Shoba Ekambaram, et al. · Aging

Advancing prediction of age-related vascular cognitive impairment based on peripheral and retinal vascular health in a pilot study: a novel comprehensive assessment developed for a prospective workplace-based cohort (The Semmelweis Study)

2024 · Tamas Csipo, Agnes Lipecz, et al. · GeroScience · 14

Palmitic Acid Induces Oxidative Stress and Senescence in Human Brainstem Astrocytes, Downregulating Glutamate Reuptake Transporters—Implications for Obesity-Related Sympathoexcitation

2024 · Mahesh Kumar Sivasubramanian, Raisa Monteiro, et al. · Nutrients · 14

Chronic β3‐ AR stimulation activates distinct thermogenic mechanisms in brown and white adipose tissue and improves systemic metabolism in aged mice

2024 · Duraipandy Natarajan, Bhuvana Plakkot, et al. · Aging Cell · 29

Chronic β3 adrenergic agonist treatment improves brain microvascular endothelial function and cognition in aged mice

2024 · Duraipandy Natarajan, Shoba Ekambaram, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1

Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment

2024 · Cameron D. Owens, Camila Bonin Pinto, et al. · Alzheimer s & Dementia · 52

Longitudinal detection of gait alterations associated with hypertension-induced cerebral microhemorrhages in mice: predictive role of stride length and stride time asymmetry and increased gait entropy

2024 · Zoltan Ungvari, Mihaly Muranyi, et al. · GeroScience · 9

Accelerated Aging Induced by an Unhealthy High-Fat Diet: Initial Evidence for the Role of Nrf2 Deficiency and Impaired Stress Resilience in Cellular Senescence

2024 · Priya Balasubramanian, Tamas Kiss, et al. · Nutrients · 34

Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence

2024 · Anna Ungvari, Tamas Kiss, et al. · GeroScience · 18

Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors

2023 · Rafal Gulej, Ádám Nyúl-Tóth, et al. · GeroScience · 50

PCSK9: an emerging player in cardiometabolic aging and its potential as a therapeutic target and biomarker

2023 · Anna Csiszar, Stefano Tarantini, et al. · GeroScience · 14

Preventing spontaneous cerebral microhemorrhages in aging mice: a novel approach targeting cellular senescence with ABT263/navitoclax

2023 · Janet Faakye, Ádám Nyúl-Tóth, et al. · GeroScience · 39

Whole brain irradiation–induced endothelial dysfunction in the mouse brain

2023 · Tamas Kiss, Anna Ungvari, et al. · GeroScience · 15