Investigation on pathological implications of guidance molecules in neuro-immune-metabolism.
Description: To elucidate the regulatory mechanisms of immune and inflammatory cell activation and differentiation by regulatory molecules controlling neuroimmunometabolism, we found that LRRK2, the gene responsible for Parkinson's disease, a neurodegenerative disease, and its analog LRRK1 are responsible for the physiological activity of semaphorins through the regulation of activation of the small G protein Rab7. We found that LRRK2, a gene responsible for Parkinson's disease, and its analog LRRK1 are responsible for the physiological activity of semaphorins via regulating the activation of small G protein Rab7. Regarding the analysis of intracellular metabolic changes involved in immune and inflammatory cell differentiation, we found that activation of intracellular lipid metabolism via the mTOR-Sema6D-PPARγ pathway is essential during inhibitory macrophage differentiation and suppresses the development of enteritis.
Amount: ¥192,100,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (S)
Start date: 2018-06-11
End date: 2023-03-31
Investigator: Atsushi Kumanogoh
Institution: Osaka University
Funded outputs count: 111
Funder award ID: 18H05282
OpenAlex ID: G4276115010