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Hyperactive mobile DNA in schizophrenia

Description: Schizophrenia affects 1 in 100 people, and yet its causes remain largely unclear. To improve understanding, treatment and management of the disease, the team performing this research will evaluate whether mobile DNA elements found in our genome are activated by stress and thereby alter how brain cells work in individuals affected by schizophrenia. They will also test whether mobile DNA can be blocked by drugs, perhaps revealing new strategies to treat the disease.
Amount: A$725,600
Funding type: research
Funder scheme: Project Grants - Standard Project Grant
Start date: 2018-01-01
End date: 2020-12-31
Investigator: Geoffrey Faulkner
Institution: University of Queensland
Funded outputs count: 13
Funder award ID: 1138795
OpenAlex ID: G4311404944
2022 · Patricia Gerdes, Sue Mei Lim, et al. · Nature Communications · 25
2022 · Julio Aguado, Cecilia Gómez-Inclán, et al. · Ageing Research Reviews · 46
2022 · Mohammed R. Shaker, Amna Kahtan, et al. · Frontiers in Cell and Developmental Biology · 20
2021 · Mohammed R. Shaker, Julio Aguado, et al. · npj Aging and Mechanisms of Disease · 49
2021 · Mohammed R. Shaker, Giovanni Pietrogrande, et al. · Frontiers in Cellular Neuroscience · 92
2020 · Adam D. Ewing, Nathan Smits, et al. · Molecular Cell · 194
2020 · Mohammed R. Shaker, Justin Cooper-White, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 5
2020 · Julio Aguado, Fabrizio d’Adda di Fagagna, et al. · Ageing Research Reviews · 79
2019 · Francisco J. Sanchez-Luque, Marie-Jeanne H.C. Kempen, et al. · Molecular Cell · 161
2019 · Carmen Salvador-Palomeque, Francisco J. Sanchez-Luque, et al. · Molecular and Cellular Biology · 25
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