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Multicenter Osteoarthritis Study (MOST) Second Renewal

Description: PUBLIC HEALTH RELEVANCE: Knee osteoarthritis which causes chronic knee pain affects at least 12% of persons age 60 and over and is the most common cause of disability in elders, yet little is available to treat or prevent this disease. We propose a renewal of the Multicenter Osteoarthritis Study (MOST), focused on new prevention opportunities and also on novel ways to understand and ultimately limit the impact of knee arthritis on the daily lives of those affecte.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2001-01-01
End date: 2022-05-31
Investigator: MICHAEL C NEVITT
Institution: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Subfield: Rheumatology
Field: Medicine
Funded outputs count: 285
Funder award ID: U01AG019069
OpenAlex ID: G5090531137
Evaluating the C-score from weight-bearing CT as a quantitative imaging biomarker for worsening knee osteoarthritis structure and pain in the multicenter osteoarthritis study
2026 · S. Li, N.A. Segal, et al. · Osteoarthritis and Cartilage
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Genetic and Population Analyses Implicate Thyroid‐Related Regulation of RNF144B in Chondrocalcinosis
2026 · Yahong Wu, Yanning Xu, et al. · Arthritis & Rheumatology
Forecasting knee arthroplasty surgery with deep learning
2026 · Omar Musbahi, Thomas A. G. Hall, et al. · Bone & Joint Open · 1
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3-D landmarking repeatability emphasizes challenges in scan positioning during weight bearing CT of the knee
2026 · T.D. Turmezei, A. Boddu, et al. · Osteoarthritis Imaging
Does fat mass contribute to knee osteoarthritis risk beyond weight itself? Data from the Multicenter Osteoarthritis Study
2026 · K. Godziuk, S. Tilley, et al. · Osteoarthritis and Cartilage
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The association of CT-detected intra-articular calcification with MRI-detected effusion-synovitis and Hoffa-synovitis in knee OA: The Multicenter Osteoarthritis study
2026 · Jean W. Liew, Mohamed Jarraya, et al. · Osteoarthritis and Cartilage
Health‐Related Behaviors Associated With Knee Pain Increase: A Longitudinal Community‐Based Cohort Study That Examines Osteoarthritis
2026 · Morgan L. Wolff, Sarah H. Nash, et al. · ACR Open Rheumatology
Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study
2026 · Kristine Godziuk, Sarah Tilley, et al. · Arthritis Care & Research
Association of Wearable Sensor–Derived Gait Measures With Cartilage Damage Over Two Years Among Adults With or at Risk of Knee Osteoarthritis
2026 · Kathryn L. Bacon, David T. Felson, et al. · Arthritis Care & Research · 2
Magnetic resonance imaging-defined knee osteoarthritis rarely occurs without cartilage damage
2025 · Alison H. Chang, Leena Sharma, et al. · Osteoarthritis and Cartilage Open · 3
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Baseline 3D joint space width on weight-bearing CT in comparison with 2D JSWx on radiographs for predicting 24-month worsening of knee structure in the multicenter osteoarthritis study
2025 · Ryo Yoshikawa, Ali Guermazi, et al. · Osteoarthritis Imaging
Cam morphology and the risk of developing radiographic hip osteoarthritis within 8 years: an individual participant data meta-analysis of 23 886 hips from the world COACH consortium
2025 · Jinchi Tang, Fleur Boel, et al. · British Journal of Sports Medicine · 6
Relation of vertical ground reaction forces while walking to contralateral structural worsening in adults with unilateral knee osteoarthritis: the Multicenter Osteoarthritis Study
2025 · Patrick Corrigan, Cara L. Lewis, et al. · Clinical Biomechanics · 1
Response to letter to the editor regarding ‘The relation of walking forces to structural damage in the knee: The Multicenter Osteoarthritis Study’
2025 · Lauren K. Sara, David T. Felson, et al. · Osteoarthritis and Cartilage
Usefulness of 3D joint space width on weight-bearing CT in comparison with 2D joint space width on radiographs for predicting 24-month worsening of knee osteoarthritis pain and function in the MOST study
2025 · Ryo Yoshikawa, Neil A. Segal, et al. · Osteoarthritis and Cartilage · 4
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Severe pincer morphology is associated with incident hip osteoarthritis: prospective individual participant data from 18 935 hips from the World COACH consortium
2025 · Noortje Riedstra, Fleur Boel, et al. · British Journal of Sports Medicine · 2
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Breaking down tibial tuberosity to trochlear groove distance into two components to enable patient-specific treatment strategies
2025 · Johannes M. Sieberer, Nancy Park, et al. · Journal of ISAKOS Joint Disorders & Orthopaedic Sports Medicine · 5
Effect of Knee Extensor Power on Knee Pain in Adults With or at Risk for Osteoarthritis: The Multicenter Osteoarthritis Study
2025 · Chun-Hao Huang, Neil A. Segal, et al. · The Journal of Rheumatology
Measures of Patellofemoral Morphology Predict the Risk of Local Cartilage Damage Progression: A Yale/MOST Collaborative Study
2025 · Nancy Park, Johannes M. Sieberer, et al. · The American Journal of Sports Medicine · 7
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Does hsCRP provide insights into an inflammatory phenotype of knee osteoarthritis?
2025 · Navya George, Jean W. Liew, et al. · Osteoarthritis and Cartilage · 1
Longitudinal Trajectories of Pain Sensitization Over Nine Years in People With or at Risk of Knee Osteoarthritis
2025 · Kosaku Aoyagi, Na Wang, et al. · Arthritis Care & Research · 4
Chondrocalcinosis and incident knee osteoarthritis: findings from 2 large prospective cohorts with 20 years of follow-up
2025 · Yahong Wu, Jean W. Liew, et al. · Annals of the Rheumatic Diseases · 7
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Evaluation of neuropathic-like symptoms and objective signs of neuropathy post-knee replacement in patients with knee osteoarthritis
2025 · Devin Driscoll, Priyanka Ballal, et al. · Osteoarthritis and Cartilage Open · 2
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A Progressive risk formulation for enhanced deep learning based total knee replacement prediction in knee osteoarthritis
2025 · Haresh Rengaraj Rajamohan, Richard Kijowski, et al. · Signal Image and Video Processing · 2
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The relation of walking forces to structural damage in the knee: The Multicenter Osteoarthritis Study
2025 · Lauren K. Sara, David T. Felson, et al. · Osteoarthritis and Cartilage · 9
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