Analyses of causes anf treatment for persistent sarcopenia after AKI
Description: We examined whether early intervention with treadmill exercise and branched-chain amino acids (BCAA) can prevent AKI-induced muscle wasting and reduced physical performance in mice. Unilateral 15 min ischemia-reperfusion injury was induced in contralateral nephrectomized mice, and muscle histological and physiological changes were assessed under pair-feeding. The mice exercised for 30 min each day and received oral BCAA for 7 days after AKI insult. By day 7, ischemic AKI significantly decreased the wet weight, myofiber cross-sectional area, and central mitochondrial volume density of the anterior tibialis muscle and significantly reduced maximal exercise time. Regular exercise and BCAA prevented AKI-induced muscle atrophy and low physical performance by suppressing myostatin and atrogin-1 mRNA upregulation and restoring reduced phosphorylated Akt and PGC-1α mRNA expression in the muscle.
Amount: ¥4,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: AKIHIKO KATO
Institution: Hamamatsu University School of Medicine
Funded outputs count: 0
Funder award ID: 18K11070
OpenAlex ID: G4360099396