Care prevention: Evaluation of motor function and effective intervention strategy based on salivary neurotrophic factor
Description: We investigated how exercise effectively increased salivary brain-derived neurotrophic factor (BDNF) levels. Salivary BDNF levels decreased markedly with age but were higher in elderly individuals who exercised regularly, went out often, and had frequent social interactions. Salivary BDNF did not correlate with limb skeletal muscle mass index (SMI) but did correlate with motivation.Salivary BDNF levels increased with mastication; the levels remained elevated for over 1 hour after mastication stopped. These findings provide a scientific basis for factors known to prevent dementia, such as moderate exercise, social activity, and chewing well. We are now aiming to validate the effects of playing wind instruments, harmonicas, and singing as well as of combinations of these with exercise and brain training on the dynamics of salivary BDNF.
Amount: ¥16,770,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Mari Sanai
Institution: Hiroshima Bunka Gakuen University
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 0
Funder award ID: 16H05603
OpenAlex ID: G4367703673