Uncovering Prolonged Mitosis as a Fundamental Feature of Aging
Description: Aging is associated with the accumulation of senescent cells, but the triggers of this accumulation remain unclear. This project proposes that prolonged mitosis acts as a novel driver of aging by activating the mitotic stopwatch (USP28/53BP1/p53) pathway. By combining live-cell imaging, omics approaches, and genetic models, this study will identify the causes of mitotic delay, particularly centrosome dysfunction, and determine how prolonged mitosis contributes to senescence, establishing a new link between mitotic defects and aging.
Amount: ¥4,420,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2026-04-01
End date: 2029-03-31
Investigator: Md・Hazrat BELAL
Institution: Okinawa Institute of Science and Technology Graduate University
Funded outputs count: 0
Funder award ID: 26K18305
OpenAlex ID: G4372009344