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A possible mechanism of Alzheimer's disease caused by lipid peroxidation

Description: Alzheimer's disease is the most common type of dementia and progressive neurodegenerative disease. The recent findings suggest that lipid peroxidation plays an important role in the pathogenesis of Alzheimer's disease. It is well known that lipids are oxidized by heating to produce lipid peroxides, which further cause oxidative stress in the body. In the present study, we investigated the induction of cell death and changes in oxidative damage proteins in monkeys exposed to oxidative stress.

Funder: Japan Society for the Promotion of Science

Amount: ¥6,370,000

Funding type: research

Funder scheme: Grant-in-Aid for Challenging Research (Exploratory)

Start date: 2018-06-29

End date: 2021-03-31

Investigator: Shinji OIKAWA

Institution: Mie University

Funded outputs count: 17

Funder award ID: 18K19673

OpenAlex ID: G4427307880

Myricetin causes site-specific DNA damage via reactive oxygen species generation by redox interactions with copper ions

2023 · Yuichiro Hirao, Hatasu Kobayashi, et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 6

Copper-mediated DNA damage caused by purpurin, a natural anthraquinone

2022 · Hatasu Kobayashi, Yurie Mori, et al. · Genes and Environment · 12

Mechanism of reactive oxygen species generation and oxidative DNA damage induced by acrylohydroxamic acid, a putative metabolite of acrylamide

2021 · Yurie Mori, Hatasu Kobayashi, et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 19

Proteomic identification of the proteins related to cigarette smoke-induced cardiac hypertrophy in spontaneously hypertensive rats

2020 · Yuki Kitamura, Nathan Mise, et al. · Scientific Reports · 5

Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions

2020 · Sharif Ahmed, Hatasu Kobayashi, et al. · Scientific Reports · 16

CD44v9 Induces Stem Cell-Like Phenotypes in Human Cholangiocarcinoma

2020 · Nattawan Suwannakul, Ning Ma, et al. · Frontiers in Cell and Developmental Biology · 26

Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model

2020 · Guifeng Wang, Ning Ma, et al. · Oxidative Medicine and Cellular Longevity · 30

Proteomic analysis of liver proteins of mice exposed to 1,2-dichloropropane

2020 · Xiao Zhang, Kota Morikawa, et al. · Archives of Toxicology · 11

Polyphenols with Anti-Amyloid β Aggregation Show Potential Risk of Toxicity Via Pro-Oxidant Properties

2020 · Hatasu Kobayashi, Mariko Murata, et al. · International Journal of Molecular Sciences · 57

Combination of RERG and ZNF671 methylation rates in circulating cell‐free DNA: A novel biomarker for screening of nasopharyngeal carcinoma

2020 · Yifei Xu, Weilin Zhao, et al. · Cancer Science · 33

Proteomic analysis of the monkey hippocampus for elucidating ischemic resistance

2020 · Yurie Mori, Shinji Oikawa, et al. · Journal of Clinical Biochemistry and Nutrition · 3

Proteomic analysis of hippocampal proteins in acrylamide-exposed Wistar rats

2019 · Daichi Nagashima, Lingyi Zhang, et al. · Archives of Toxicology · 18

Anti-Cancer Mechanisms of Taurine in Human Nasopharyngeal Carcinoma Cells

2019 · Feng He, Ning Ma, et al. · Advances in experimental medicine and biology · 19

Mechanisms of DNA damage induced by morin, an inhibitor of amyloid β-peptide aggregation

2018 · Yurie Mori, Shinya Kato, et al. · Free Radical Research · 11

Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation

2018 · Nattawan Suwannakul, Ning Ma, et al. · Mediators of Inflammation · 25

Proteomic Profiling of Exosomal Proteins for Blood-based Biomarkers in Parkinson's Disease

2018 · Yuki Kitamura, Midori Kojima, et al. · Neuroscience · 102

Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro

2018 · Feng He, Ning Ma, et al. · Amino Acids · 30