The Functions of Novel FOXN1 Compound Heterozygous Mutations in PIDs Patients
Description: Project Narrative The thymus is an organ where the T cells of the immune system develop. Infants born with mutations in the gene encoding FOXN1 do not develop a thymus and suffer from a severe combined immunodeficiency. We will develop mouse models with mutations in Foxn1 that match those in the patients to a) understand how Foxn1 causes the immune problems and b) improve survival chances in these patients.
Funding type: research
Funder scheme: R21
Start date: 2019-01-18
End date: 2021-03-31
Investigator: NICOLAI STANISLAS CYRILLE VAN OERS
Institution: UT SOUTHWESTERN MEDICAL CENTER
Funded outputs count: 7
Funder award ID: R21AI144140
OpenAlex ID: G3536634308