More than just a load control: cytoskeletal form and function during aging
Description: Many cellular functions, such as autophagy, organelle dynamics, and endocytosis/exocytosis, as well as their dedicated quality control machineries, such as the ubiquitin-proteasome system and the heat-shock response, decline in efficiency and function during the aging process. The actin cytoskeleton is no exception, and exhibits marked decline in structural integrity and function at old age. I propose a multipronged approach to understand how the regulatory network involved in cytoskeletal maintenance deteriorates during aging, and how this contributes to the physiological consequences of aging.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R00
Start date: 2020-05-01
End date: 2024-05-31
Investigator: RYO HIGUCHI-SANABRIA
Institution: UNIVERSITY OF SOUTHERN CALIFORNIA
Funded outputs count: 34
Funder award ID: R00AG065200
OpenAlex ID: G875742055