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Development of an Innovative Vervet (Chlorocebus aethiops sabaeus) Model of Early Alzheimer's-like Neuropathology and Symptomatology

Description: This project will further establish a novel and promising model of late-onset sporadic Alzheimer’s disease – the most common type – in vervet monkeys. Development of this novel animal model will yield insights into the causes and early neuropathology of Alzheimer’s disease, and identify promising targets for early intervention that could alter the course of this devastating disease.
Funding type: research
Funder scheme: R24
Start date: 2021-09-15
End date: 2026-05-31
Investigator: SUZANNE CRAFT (lead)
Funded outputs count: 26
Funder award ID: R24AG073199
OpenAlex ID: G1392075037
Plasma and cerebrospinal fluid proteomics reveal distinct patterns of senescence and neuropathology in aging rhesus macaques
2026 · Giovanne B. Diniz, Kayla Schwartz, et al. · GeroScience
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PET imaging utility of a novel Aβ-tracking PET radiotracer, [18F]FC119S in aged vervet monkeys
2026 · Bhuvanachandra Bhoopal, Brett M. Frye, et al. · Journal of Translational Medicine · 2
Age, glucose tolerance, and cognitive performance in female vervet monkeys
2025 · Brett M. Frye, Trinity G. Davis, et al. · GeroScience · 2
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Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers
2025 · D. Luke Fischer, Lea T. Grinberg, et al. · Alzheimer s & Dementia · 6
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ZipAEr: A compressive convolutional autoencoder for high-dimensional spatial omics data at subcellular resolution
2025 · Habil Zare, Shiva Kazempour, et al. · Research Square
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Identification of markers for neurescence through transcriptomic profiling of postmortem human brains
2025 · Shiva Kazempour Dehkordi, Sogand Sajedi, et al. · npj Aging · 2
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Effects of Diminished Cerebrospinal Fluid Flow in the Spinal Canal on Amyloid Pathophysiology in Vervet Monkeys
2025 · Jeongchul Kim, Megan E. Lipford, et al. · Research Square · 1
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Spatial proteomic differences in chronic traumatic encephalopathy, Alzheimer's disease, and primary age‐related tauopathy hippocampi
2024 · Timothy E. Richardson, Miranda E. Orr, et al. · Alzheimer s & Dementia · 12
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Circulating small extracellular vesicles as blood-based biomarkers of muscle health in aging nonhuman primates
2024 · Shalini Mishra, Ashish Kumar, et al. · GeroScience · 3
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Comparative lifespan and healthspan of nonhuman primate species common to biomedical research
2024 · Hillary F. Huber, Hannah C. Ainsworth, et al. · GeroScience · 25
Defining and characterizing neuronal senescence, ‘neurescence’, as GX arrested cells
2024 · Hannah R. Hudson, Markus Riessland, et al. · Trends in Neurosciences · 23
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Therapeutic targeting of senescent cells in the CNS
2024 · Markus Riessland, Methodios Ximerakis, et al. · Nature Reviews Drug Discovery · 82
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A Need for Refined Senescence Biomarkers and Measures of Senolytics in the Brain
2024 · Miranda E. Orr · Journal of Alzheimer s Disease · 6
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Effects of multiple anesthetic exposures on rhesus macaque brain development: a longitudinal structural MRI analysis
2023 · Jeongchul Kim, Richard Barcus, et al. · Cerebral Cortex · 1
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Development and assessment of a stair ascension challenge as a measure of aging and physical function in nonhuman primates
2023 · Shannon R. Scarberry, Hannah Prutchi, et al. · American Journal of Primatology · 2
Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics
2023 · M. Riessland, Miranda E. Orr · The Journal of Prevention of Alzheimer s Disease · 58
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Spatial proteomics of hippocampal subfield‐specific pathology in Alzheimer's disease and primary age‐related tauopathy
2023 · Jamie M. Walker, Miranda E. Orr, et al. · Alzheimer s & Dementia · 46
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Preliminary PET Imaging of Microtubule-Based PET Radioligand [11C]MPC-6827 in a Nonhuman Primate Model of Alzheimer’s Disease
2023 · Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, et al. · ACS Chemical Neuroscience · 10
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Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial
2023 · Mitzi M. Gonzales, Valentina R. Garbarino, et al. · Nature Medicine · 343
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Executive function mediates age-related variation in social integration in female vervet monkeys (Chlorocebus sabaeus)
2023 · Jacob D. Negrey, Brett M. Frye, et al. · GeroScience · 8
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Early Alzheimer's disease‐like reductions in gray matter and cognitive function with aging in nonhuman primates
2022 · Brett M. Frye, Suzanne Craft, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 24
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Transcriptional profiles in olfactory pathway–associated brain regions of African green monkeys: Associations with age and Alzheimer's disease neuropathology
2022 · Jacob D. Negrey, Dorothy L. Dobbins, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 10
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Single-synapse analyses of Alzheimer’s disease implicate pathologic tau, DJ1, CD47, and ApoE
2021 · Thanaphong Phongpreecha, Chandresh R. Gajera, et al. · Science Advances · 28
Nonhuman primates at the intersection of aging biology, chronic disease, and health: An introduction to the American Journal of Primatology Special Issue on aging, cognitive decline, and neuropathology in nonhuman primates
2021 · Carol A. Shively, Agnès Lacreuse, et al. · American Journal of Primatology · 24
Isoform-specific dysregulation of AMP-activated protein kinase signaling in a non-human primate model of Alzheimer's disease
2021 · Xin Wang, Xueyan Zhou, et al. · Neurobiology of Disease · 14
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