Pyruvate and acetate metabolism after TBI: implications for cerebral energy metabolism
Description: A substantial number of deaths or permanent disability are contributed by traumatic brain injury (TBI). After the initial primary injury, complex pathophysiological secondary injuries occur over minutes to months with several complex complications, which provides a potential therapeutic window. The overall goal of this proposal is to develop hyperpolarized 13C MRS as a new metabolic imaging tool for the noninvasive diagnosis of TBI metabolism, better understanding of the secondary injury mechanism, and timely therapeutic interventions.
Funding type: research
Funder scheme: R01
Start date: 2020-09-01
End date: 2025-08-31
Investigator: JAE MO PARK
Institution: UT SOUTHWESTERN MEDICAL CENTER
Funded outputs count: 28
Funder award ID: R01NS107409
OpenAlex ID: G2567725453