Award

Enhanced Delivery Ecosystem for Neurosurgery in 2020

Description: Due to an aging population and the spiralling cost of brain disease in Europe and beyond, EDEN2020 aims to develop the gold standard for one-stop diagnosis and minimally invasive treatment in neurosurgery. Supported by a clear business case, it will exploit the unique track record of leading research institutions and key industrial players in the field of surgical robotics to overcome the current technological barriers that stand in the way of real clinical impact. EDEN2020 will provide a step change in the modelling, planning and delivery of diagnostic sensors and therapies to the brain via flexible surgical access, with an initial focus on cancer therapy. It will engineer a family of steerable catheters for chronic disease management that can be robotically deployed and kept in situ for extended periods. The system will feature enhanced autonomy, surgeon cooperation, targeting proficiency and fault tolerance with a suite of technologies that are commensurate to the unique challenges of neurosurgery. Amongst these, the system will be able to sense and perceive intraoperative, continuously deforming, brain anatomy at unmatched accuracy, precision and update rates, and deploy a range of diagnostic optical sensors with the potential to revolutionise today’s approach to brain disease management. By modelling and predicting drug diffusion within the brain with unprecedented fidelity, EDEN2020 will contribute to the wider clinical challenge of extending and enhancing the quality of life of cancer patients – with the ability to plan therapies around delicate tissue structures and with unparalleled delivery accuracy. EDEN2020 is strengthened by a significant industrial presence, which is embedded within the entire R&D process to enforce best practices and maximise translation and the exploitation of project outputs. As it aspires to impact the state of the art and consolidate the position of European industrial robotics, it will directly support the Europe 2020 Strategy.
Amount: €8,361,000
Funding type: research
Funder scheme: H2020 - RIA
Start date: 2016-04-01
End date: 2021-09-30
Institution: IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Funded outputs count: 51
Funder award ID: 688279
OpenAlex ID: G4487409002
2026 · CASTELLANO, Antonella, Pieri, Valentina, et al. · Zenodo (CERN European Organization for Nuclear Research)
2025 · Antonella Castellano, Valentina Pieri, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
2022 · Andrea Bernardini, Marco Trovatelli, et al. · Communications Biology · 14
2022 · Ardit Ramadani, Mai Bui, et al. · Medical Image Analysis · 54
2022 · Tian Yuan, Wenbo Zhan, et al. · Biomechanics and Modeling in Mechanobiology · 24
2022 · Asad Jamal, Tian Yuan, et al. · International Journal of Molecular Sciences · 27
2022 · Marco Trovatelli, Carlotta Spediacci, et al. · BMC Veterinary Research · 6
2021 · Marco Vidotto, Andrea Bernardini, et al. · Proceedings of the National Academy of Sciences · 27
2021 · Tommaso Sciortino, Riccardo Secoli, et al. · Cancers · 41
2021 · Alice Segato, Chiara Di Vece, et al. · IEEE Robotics and Automation Letters · 20
2021 · Bernardini, Andrea, Trovatelli, Marco, et al. · Zenodo (CERN European Organization for Nuclear Research) · 1
2021 · Marco Trovatelli, Stefano Brizzola, et al. · International Journal of Medical Robotics and Computer Assisted Surgery · 6
2021 · Andi Dine, Edward Bentley, et al. · HardwareX · 18
2021 · Alberto Favaro, Alice Segato, et al. · IEEE Transactions on Robotics · 41
2020 · Alice Segato, Valentina Corbetta, et al. · IEEE Transactions on Medical Robotics and Bionics · 22
2020 · Castellano, Antonella, Pieri, Valentina, et al. · Zenodo (CERN European Organization for Nuclear Research) · 2
2020 · Marco Riva, Egesta Lopci, et al. · Neurosurgery Clinics of North America · 8
2020 · Alberto Favaro, Riccardo Secoli, et al. · IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)
2020 · Alice Segato, Aldo Marzullo, et al. · APL Bioengineering · 169
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