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DK19289

Funded outputs count: 136
Funder award ID: DK19289
OpenAlex ID: G4489355756
TSH Receptor Cleavage Into Subunits and Shedding of the A-Subunit; A Molecular and Clinical Perspective
2016 · Basil Rapoport, Sandra M. McLachlan · Endocrine Reviews · 83
Deleting the Redundant TSH Receptor C-Peptide Region Permits Generation of the Conformationally Intact Extracellular Domain by Insect Cells
2015 · Chun-Rong Chen, Larry M. Salazar, et al. · Endocrinology · 5
Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease
2015 · Basil Rapoport, Holly A. Aliesky, et al. · The Journal of Clinical Endocrinology & Metabolism · 32
A Unique Mouse Strain That Develops Spontaneous, Iodine-Accelerated, Pathogenic Antibodies to the Human Thyrotrophin Receptor
2015 · Basil Rapoport, Holly A Aliesky, et al. · The Journal of Immunology · 38
Crystal Structure of a TSH Receptor Monoclonal Antibody: Insight Into Graves' Disease Pathogenesis
2014 · Chun-Rong Chen, Paul A. Hubbard, et al. · Molecular Endocrinology · 24
Graves' Hyperthyroidism Is Antibody-Mediated But Is Predominantly a Th1-Type Cytokine Disease
2014 · Basil Rapoport, Sandra M. McLachlan · The Journal of Clinical Endocrinology & Metabolism · 86
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Thyroid Autoantibodies Are Rare in Nonhuman Great Apes and Hypothyroidism Cannot Be Attributed to Thyroid Autoimmunity
2013 · Holly Aliesky, Cynthia L. Courtney, et al. · Endocrinology · 27
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Breaking Tolerance to Thyroid Antigens: Changing Concepts in Thyroid Autoimmunity
2013 · Sandra M. McLachlan, Basil Rapoport · Endocrine Reviews · 249
Probing Structural Variability at the N Terminus of the TSH Receptor with a Murine Monoclonal Antibody That Distinguishes between Two Receptor Conformational Forms
2012 · Sepehr Hamidi, Chun-Rong Chen, et al. · Endocrinology · 8
Thyrotropin-Blocking Autoantibodies and Thyroid-Stimulating Autoantibodies: Potential Mechanisms Involved in the Pendulum Swinging from Hypothyroidism to Hyperthyroidism or Vice Versa
2012 · Sandra M. McLachlan, Basil Rapoport · Thyroid · 239
The Thyrotropin Receptor Hinge Region as a Surrogate Ligand: Identification of Loci Contributing to the Coupling of Thyrotropin Binding and Receptor Activation
2012 · Chun-Rong Chen, Larry M. Salazar, et al. · Endocrinology · 11
Genetic Linkages for Thyroxine Released in Response to Thyrotropin Stimulation in Three Sets of Recombinant Inbred Mice Provide Evidence for Shared and Novel Genes Controlling Thyroid Function
2012 · Sepehr Hamidi, Holly A. Aliesky, et al. · Thyroid · 5
Breaking Tolerance in Transgenic Mice Expressing the Human TSH Receptor A-Subunit: Thyroiditis, Epitope Spreading and Adjuvant as a ‘Double Edged Sword’
2012 · Sandra M. McLachlan, Holly A. Aliesky, et al. · PLoS ONE · 19
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Role of Self-Tolerance and Chronic Stimulation in the Long-Term Persistence of Adenovirus-Induced Thyrotropin Receptor Antibodies in Wild-Type and Transgenic Mice
2012 · Sandra M. McLachlan, Holly A. Aliesky, et al. · Thyroid · 13
Novel Information on the Epitope of an Inverse Agonist Monoclonal Antibody Provides Insight into the Structure of the TSH Receptor
2012 · Chun-Rong Chen, Larry M. Salazar, et al. · PLoS ONE · 5
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Deletion of thyrotropin receptor residue Asp403 in a hyperfunctioning thyroid nodule provides insight into the role of the ectodomain in ligand-induced receptor activation.
2012 · E Nishihara, C-R Chen, et al. · PubMed · 11
Review and Hypothesis: Does Graves' Disease Develop in Non-Human Great Apes?
2011 · Sandra M. McLachlan, Kristine Alpi, et al. · Thyroid · 27
Insight into Thyroid-Stimulating Autoantibody Interaction with the Thyrotropin Receptor N-Terminus Based on Mutagenesis and Re-Evaluation of Ambiguity in This Region of the Receptor Crystal Structure
2011 · Sepehr Hamidi, Chun-Rong Chen, et al. · Thyroid · 10
Exceptional Hyperthyroidism and a Role for both Major Histocompatibility Class I and Class II Genes in a Murine Model of Graves' Disease
2011 · Sandra M. McLachlan, Holly A. Aliesky, et al. · PLoS ONE · 9
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An Attempt to Induce “Graves' Disease of the Gonads” by Immunizing Mice with the Luteinizing Hormone Receptor Provides Insight into Breaking Tolerance to Self-Antigens
2011 · Chun-Rong Chen, Holly A. Aliesky, et al. · Thyroid · 3
Distinct Genetic Signatures for Variability in Total and Free Serum Thyroxine Levels in Four Sets of Recombinant Inbred Mice
2011 · Sandra M. McLachlan, Lu Lu, et al. · Endocrinology · 6
Evidence That the Thyroid-stimulating Hormone (TSH) Receptor Transmembrane Domain Influences Kinetics of TSH Binding to the Receptor Ectodomain
2010 · Chun-Rong Chen, Sandra M. McLachlan, et al. · Journal of Biological Chemistry · 19
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Relationship between Thyrotropin Receptor Hinge Region Proteolytic Posttranslational Modification and Receptor Physiological Function
2010 · Sepehr Hamidi, Chun-Rong Chen, et al. · Molecular Endocrinology · 18
Subclinical Nonautoimmune Hyperthyroidism in a Family Segregates with a Thyrotropin Receptor Mutation with Weakly Increased Constitutive Activity
2010 · Eijun Nishihara, Chun-Rong Chen, et al. · Thyroid · 16
Variable Suppression of Serum Thyroxine in Female Mice of Different Inbred Strains by Triiodothyronine Administered in Drinking Water
2010 · Sepehr Hamidi, Holly Aliesky, et al. · Thyroid · 15
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